Heat-shock proteins as dendritic cell-targeting vaccines - getting warmer

Heat-shock proteins as dendritic cell-targeting vaccines--getting warmer.

Heat-shock proteins (hsp) provide a natural link between innate and adaptive immune responses by combining the ideal properties of antigen carriage (chaperoning), targeting and activation of antigen-presenting cells (APC), including dendritic cells (DC). Targeting is achieved through binding of hsp to distinct cell surface receptors and is followed by antigen internalization, processing and pre...

Heat shock proteins and their use as anticancer vaccines.

Giorgio Parmiani, Alessandro Testori, Michele Maio, Chiara Castelli, Licia Rivoltini, Lorenzo Pilla, Filiberto Belli, Vincenzo Mazzaferro, Jorgelina Coppa, Roberto Patuzzo, Mario R. Sertoli, Axel Hoos, Pramod K. Srivastava, and Mario Santinami Istituto Nazionale Tumori and European Institute of Oncology, Milan, Italy; University of Siena, Siena, and Istituto Scientifico Tumori, Genoa, Italy; an...

HDAC Inhibitors and Heat Shock Proteins (Hsps)

Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...

Cell surface targeting of heat shock protein gp96 induces dendritic cell maturation and antitumor immunity.

gp96 is a residential heat shock protein of the endoplasmic reticulum that has been implicated in the activation of dendritic cells (DCs) for the initiation of adaptive immunity. By genetic targeting of gp96 onto the cell surface, we demonstrate that direct access of gp96 to DCs induces their maturation, resulting in secretion of proinflammatory cytokines IL-1beta, IL-12, and chemokine monocyte...

Antitumor Immunity gp96 Induces Dendritic Cell Maturation and Cell Surface Targeting of Heat Shock Protein